Recovery of cognitive function in neuropsychiatric Langerhan’s cell histiocytosis


Mark Walterfang, FRANZCP, Level 2, John Cade Building, Royal Melbourne Hospital, Melbourne 3050, Australia. Email:


Abstract  Langerhan’s cell histiocytosis (LCH) has been described as a progressive neurological disorder marked by neurological and cognitive decline. The authors here report a case of a childhood LCH sufferer who made a significant recovery of neuropsychological function in the absence of motor recovery in late adolescence. This differential recovery of motor and cognitive functioning may relate to the interaction between LCH and childhood and adolescent neurodevelopmental processes.