Brain glucose metabolism and temperament in relation to severe somatization
Article first published online: 15 NOV 2006
Psychiatry and Clinical Neurosciences
Volume 60, Issue 6, pages 669–675, December 2006
How to Cite
HAKALA, M., VAHLBERG, T., NIEMI, P. M. and KARLSSON, H. (2006), Brain glucose metabolism and temperament in relation to severe somatization. Psychiatry and Clinical Neurosciences, 60: 669–675. doi: 10.1111/j.1440-1819.2006.01581.x
- Issue published online: 15 NOV 2006
- Article first published online: 15 NOV 2006
- Received 26 December 2005; revised 17 Arpil 2006; accepted 14 May 2006.
- basal ganglia;
- 2-[18F]-fluoro-2-deoxy-D-glucose–positron emission tomography;
- logistic regression;
- somatoform disorders;
Abstract Little is known about the pathophysiology of somatization. The authors’ aim was to explore associated factors with somatoform disorders. The authors studied 10 female patients with a diagnosis of somatization disorder or undifferentiated somatoform disorder with no comorbid current Diagnostic and Statistical Manual of Mental Disorders (4th edn) Axis I disorder and 12 healthy female volunteers. The predicting variables were temperament factors of the 240-item Temperament and Character Inventory instrument and regional brain glucose metabolism. Low novelty-seeking and high harm avoidance temperament traits and low caudate and low putamen glucose metabolism were statistically significantly associated with severe somatization (P < 0.05). In the present study, severe somatization associates with both altered brain glucose metabolism and temperament factors. No other studies on association of somatization with brain glucose metabolism and temperament have been published. The results are still considered exploratory due to the small number of subjects.