Schizotypy, attention deficit hyperactivity disorder, and dopamine genes
Article first published online: 15 NOV 2006
Psychiatry and Clinical Neurosciences
Volume 60, Issue 6, pages 764–767, December 2006
How to Cite
ETTINGER, U., JOOBER, R., DE GUZMAN, R. and O’DRISCOLL, G. A. (2006), Schizotypy, attention deficit hyperactivity disorder, and dopamine genes. Psychiatry and Clinical Neurosciences, 60: 764–767. doi: 10.1111/j.1440-1819.2006.01594.x
- Issue published online: 15 NOV 2006
- Article first published online: 15 NOV 2006
- Received 25 January 2006; revised 13 June 2006; accepted 18 June 2006.
- catechol-O-methyltransferase gene;
Abstract Previous research has suggested that there may be overlap between schizophrenia and attention-deficit hyperactivity disorder (ADHD). The relationship between schizotypal personality traits, ADHD features and polymorphisms was evaluated in dopamine-related genes. Thirty-one healthy, Caucasian men completed the Rust Inventory of Schizotypal Cognitions (RISC) and the ADHD Self-Report Scale (ASRS). Catechol-O-methyltransferase (COMT) Val158Met, dopamine receptors of the D3 type (DRD3) Ser9Gly, DRD4 variable number of tandem repeats (VNTR), and SLC6A3 VNTR polymorphisms were analyzed. RISC score was correlated with ASRS score (r = 0.54, P = 0.003). COMT Met homozygotes had higher ASRS scores than Val homozygotes (P = 0.005). These findings are consistent with evidence of overlap between schizophrenia and ADHD and support an involvement of COMT genotype in ADHD features.