Attention and cognition in patients with obsessive–compulsive disorder
Version of Record online: 12 JAN 2007
Psychiatry and Clinical Neurosciences
Volume 61, Issue 1, pages 45–53, February 2007
How to Cite
DE GEUS, F., DENYS, D. A. J. P., SITSKOORN, M. M. and WESTENBERG, H. G. M. (2007), Attention and cognition in patients with obsessive–compulsive disorder. Psychiatry and Clinical Neurosciences, 61: 45–53. doi: 10.1111/j.1440-1819.2007.01609.x
- Issue online: 12 JAN 2007
- Version of Record online: 12 JAN 2007
- Received 17 February 2006; revised 24 July 2006; accepted 6 August 2006.
- anterior cingulate cortex;
- executive functioning;
- obsessive–compulsive disorder;
- Wisconsin Card Sorting Test
Abstract Although a dysfunctional prefrontal-striatal system is presupposed in obsessive–compulsive disorder (OCD), this is not sustained by neuropsychological studies. The aim of this study was twofold: (i) to investigate the cognitive deficits in patients with OCD compared to matched healthy controls; and (ii) to relate cognitive performance to clinical characteristics in patients with OCD. In this study, 39 patients with primary OCD according to Diagnostic and Statistical Manual, fourth edition criteria were compared to 26 healthy control subjects on a battery measuring verbal memory and executive functioning. Patients with OCD showed slowed learning on the verbal memory task and made more errors on the Wisconsin Card Sorting Test. Errors were failures to maintain set, which were related to severity of OCD symptomatology. The results show that patients with OCD have cognitive deficits. The authors hypothesize that these deficits may be interpreted by attentional deficits caused by a dysfunctional anterior cingulate cortex.