Effects of polydipsia–hyponatremia on seizures in patients with epilepsy
Article first published online: 28 APR 2007
Psychiatry and Clinical Neurosciences
Volume 61, Issue 3, pages 330–332, June 2007
How to Cite
OKAZAKI, M., ITO, M. and KATO, M. (2007), Effects of polydipsia–hyponatremia on seizures in patients with epilepsy. Psychiatry and Clinical Neurosciences, 61: 330–332. doi: 10.1111/j.1440-1819.2007.01663.x
- Issue published online: 28 APR 2007
- Article first published online: 28 APR 2007
- Received 27 September 2006; revised 1 February 2007; accepted 6 February 2007.
Abstract Aggravation of seizures due to hyponatremia was investigated in five patients with epilepsy and polydipsia–hyponatremia. They experienced marked increases in the frequency of their complex partial seizures with a decrease in the serum sodium level to 118–127 mEq/L. In all cases, the serum sodium level returned to normal through restriction of fluids, and the clinical seizures improved. All patients had shown intellectual impairment and/or psychotic episodes, and all had been given antipsychotics. Hyponatremia caused by polydipsia appears to be a risk factor for aggravation of habitual seizures in patients with epilepsy.