Antidepressant-like effects of the traditional Chinese medicine kami-shoyo-san in rats
Article first published online: 30 JUN 2007
Psychiatry and Clinical Neurosciences
Volume 61, Issue 4, pages 401–406, August 2007
How to Cite
PARK, S.-W., KIM, Y.-K., LEE, J.-G., KIM, S.-H., KIM, J.-M., YOON, J.-S., PARK, Y.-K., LEE, Y.-K. and KIM, Y.-H. (2007), Antidepressant-like effects of the traditional Chinese medicine kami-shoyo-san in rats. Psychiatry and Clinical Neurosciences, 61: 401–406. doi: 10.1111/j.1440-1819.2007.01676.x
- Issue published online: 30 JUN 2007
- Article first published online: 30 JUN 2007
- Received 6 November 2006; revised 15 February 2007; accepted 4 March 2007.
- forced swimming test;
- immobilization stress;
Abstract Kami-shoyo-san (KSS), a traditional Chinese medicine, has been used to treat patients with neuropsychiatric disorders. The aim of the present paper was to investigate whether KSS has antidepressant-like effects, and to assess its mechanism of action, using male Sprague–Dawley rats given 10-fold (KSS 10X) or 20-fold (KSS 20X) the typical human daily dosage. Immobility time was measured by the forced swimming test, and hippocampal neurogenesis was quantified under immobilization stress. Rats given KSS 20X, but not those given KSS 10X, had a significantly lower immobility time and improved neurogenesis in the hippocampus. These results suggest that KSS possesses an antidepressant-like effect at a behavioral and molecular level.