T-helper 1/T-helper 2 cytokine imbalance and clinical phenotypes of acute-phase major depression
Version of Record online: 30 JUN 2007
Psychiatry and Clinical Neurosciences
Volume 61, Issue 4, pages 415–420, August 2007
How to Cite
HUANG, T.-L. and LEE, C.-T. (2007), T-helper 1/T-helper 2 cytokine imbalance and clinical phenotypes of acute-phase major depression. Psychiatry and Clinical Neurosciences, 61: 415–420. doi: 10.1111/j.1440-1819.2007.01686.x
- Issue online: 30 JUN 2007
- Version of Record online: 30 JUN 2007
- Received 4 December 2006; revised 4 April 2007; accepted 15 April 2007.
- major depression;
Abstract Several studies have discussed the relationships between T-helper 1 (Th1) or Th2 cytokines and major depression. The aim of the present study was to investigate the relationships between Th1/Th2 cytokine balance and clinical phenotypes of acute-phase major depression. A total of 82 subjects including 42 patients with major depressive disorder and 40 healthy controls were recruited. Serum cytokine levels of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and IL-10 were examined. Using ancova with age and body mass index (BMI) adjustments, there were no significant differences in serum IL-1β, TNF-α, and IL-10 levels between patients with major depressive disorder and healthy controls. However, using ancova with BMI adjustment only, the results showed that patients with major depressive disorder had significantly higher TNF-α levels than control subjects. In addition, using ancova with age and BMI adjustments, significantly higher serum IL-1β level and IL-1β/IL-10 ratio were noted in patients with melancholic features than patients with non-melancholic features. However, there were no significant differences in serum IL-1β, TNF-α and IL-10 levels between patients with and without suicide attempt. In conclusion, serum TNF-α, IL-1β level and IL-1β/IL-10 ratio might play an important role in the psychopathology of acute-phase major depressive disorder.