Three cases of schizophrenia for which olanzapine was effective after early acute phase
Article first published online: 13 FEB 2008
© 2008 The Authors
Psychiatry and Clinical Neurosciences
Volume 62, Issue 1, pages 93–97, February 2008
How to Cite
Yamamoto, N., Oda, T. and Inada, T. (2008), Three cases of schizophrenia for which olanzapine was effective after early acute phase. Psychiatry and Clinical Neurosciences, 62: 93–97. doi: 10.1111/j.1440-1819.2007.01780.x
- Issue published online: 13 FEB 2008
- Article first published online: 13 FEB 2008
- Received 20 April 2007; revised 13 September 2007; accepted 19 September 2007.
- early acute phase;
- late acute phase;
Aims: It clarifies a difference between early acute phase and late acute phase in medication.
Methods: The present report describes three patients with schizophrenia who presented with restlessness and excitement requiring hospitalization.
Results: Treatment with risperidone solution orally or parenteral haloperidol until the day after admission, followed by olanzapine, successfully improved the clinical condition of the patients. In the early stage of hospitalization, selection of fast-acting drugs that can be administered to uncooperative patients is considered preferable, focusing on rapid control of symptoms and behavioral disorders, whereas after this early stage, olanzapine is preferable for improving patient compliance in addition to stabilizing symptoms.
Conclusions: Because the target symptoms differ between the early and late acute phases, the term ‘acute phase’ used in the broad sense should be divided into two units, each requiring a different therapeutic strategy, and independent clinical approaches should be considered in order to provide more suitable treatment.