Neurocognition in first-degree healthy relatives (siblings) of bipolar affective disorder patients
Article first published online: 14 APR 2008
© 2008 The Authors
Psychiatry and Clinical Neurosciences
Volume 62, Issue 2, pages 190–196, April 2008
How to Cite
Trivedi, J. K., Goel, D., Dhyani, M., Sharma, S., Singh, A. P., Sinha, P. K. and Tandon, R. (2008), Neurocognition in first-degree healthy relatives (siblings) of bipolar affective disorder patients. Psychiatry and Clinical Neurosciences, 62: 190–196. doi: 10.1111/j.1440-1819.2008.01754.x
- Issue published online: 14 APR 2008
- Article first published online: 14 APR 2008
- Received 12 June 2007; revised 29 October 2007; accepted 5 November 2007.
- bipolar disorder;
- familial vulnerability;
Aim: Cognitive deficits have been presupposed to be endophenotypic markers in bipolar disorder, but few studies have ascertained the cognitive deficits in healthy relatives of bipolar disorder patients. The aim of the present study was to assess the cognitive functions of first-degree relatives of patients with bipolar disorder and compare them with healthy controls.
Methods: Ten first-degree apparently healthy relatives of patients with bipolar disorder were compared with 10 age- and education-matched control subjects on computer-based cognitive tests.
Results: As compared to the control group, the relatives group performed significantly poorly on tests for executive function and vigilance, while on the test for working memory the performance was not significantly different on most of the parameters.
Conclusions: Executive functioning and vigilance could be potential markers of the endophenotype in bipolar patients.