Cognitive-behavior therapy for Japanese patients with panic disorder: Acute phase and one-year follow-up results


  • Each author's contribution: Y. Nakano is the primary investigator, had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. K. Lee, Y. Noda, S; Ogawa, Y. Kinoshiota, T. Funayama, N. Watanabe, J. Chen, Y. Noguchi and T. A. Furukawa performed the clinical investigation (diagnosis, treatment, assessment and follow-up). TAF participated in the design of the study and supervised the overall conduct of the study. Y. Nakano wrote the first manuscript, all the authors took part in the rewriting of the manuscript, and all the authors approved the final manuscript.

*Yumi Nakano, MD, PhD, Department of Psychiatry and Cognitive-Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Mizuho-cho, Mizuho-ku, Nagoya 467-8601 Japan. Email:


Aim:  The aim of this paper is to report the outcomes and follow-up data of our cognitive behavioral therapy program for Japanese patients with panic disorder and to examine the baseline predictors of their outcomes.

Methods:  Seventy outpatients with panic disorder with or without agoraphobia were treated with manualized group cognitive behavioral therapy.

Results:  Fourteen patients (20%) did not complete the program. Among the completers, the average Panic Disorder Severity Scale score fell from 12.8 at baseline to 7.1 post-therapy (44.7% reduction). This effectiveness was sustained for 1 year. While controlling for the baseline severity, the duration of illness and the baseline social dysfunction emerged as significant predictors of the outcome.

Conclusions:  Our data suggest that group cognitive behavioral therapy for panic disorder can bring about as much symptom reduction among Japanese patients with panic disorder as among Western patients.