Four cases of venous thromboembolism associated with olanzapine
Article first published online: 1 DEC 2008
© 2008 The Authors. Journal compilation © 2008 Japanese Society of Psychiatry and Neurology
Psychiatry and Clinical Neurosciences
Volume 63, Issue 1, pages 116–118, February 2009
How to Cite
Maly, R., Masopust, J., Hosak, L. and Urban, A. (2009), Four cases of venous thromboembolism associated with olanzapine. Psychiatry and Clinical Neurosciences, 63: 116–118. doi: 10.1111/j.1440-1819.2008.01899.x
- Issue published online: 15 JAN 2009
- Article first published online: 1 DEC 2008
- Received 25 February 2008; revised 19 June 2008; accepted 9 September 2008.
- antipsychotic agents;
- risk factors;
- venous thromboembolism
Aims: Psychiatric disorders and treatment with conventional antipsychotic medications have been associated with venous thromboembolism, but only a few data on recent antipsychotics such as olanzapine are available.
Methods: We describe four subjects treated with olanzapine who developed venous thromboembolism, and were hospitalized at the University Hospital in Hradec Kralove during the period 2004–2006.
Results: We found a combination of several clinical and laboratory risk factors in our patients.
Conclusions: A cohort study or case–control studies are needed to better elucidate the possible role of olanzapine in etiopathogenesis of venous thromboembolism.