Antidepressant effect detected on proton magnetic resonance spectroscopy in drug-naïve female patients with first-episode major depression
Article first published online: 13 APR 2009
© 2009 The Authors. Journal compilation © 2009 Japanese Society of Psychiatry and Neurology
Psychiatry and Clinical Neurosciences
Volume 63, Issue 3, pages 350–356, June 2009
How to Cite
Kaymak, S. U., Demir, B., Oğuz, K. K., Şentürk, S. and Uluğ, B. (2009), Antidepressant effect detected on proton magnetic resonance spectroscopy in drug-naïve female patients with first-episode major depression. Psychiatry and Clinical Neurosciences, 63: 350–356. doi: 10.1111/j.1440-1819.2009.01951.x
- Issue published online: 14 MAY 2009
- Article first published online: 13 APR 2009
- Received 24 June 2008; revised 13 January 2009; accepted 25 January 2009.
- dorsolateral prefrontal cortex;
- major depressive disorder;
- N-acetyl aspartate;
- proton magnetic resonance spectroscopy
Aim: Recent neuroimaging studies support functional and structural alterations in the dorsolateral prefrontal cortex (DLPFC), particularly on the left side in patients with major depressive disorders (MDD). The aim of the present study was to examine the biochemical characteristics of left DLPFC as measured on proton (1H) magnetic resonance spectroscopy (MRS) in patients with drug-naïve first-episode MDD and a healthy control group. A second aim was to assess the effect of antidepressant treatment on the metabolites of DLPFC.
Methods: Short-echo single-voxel 1H-MRS was done for the left DLPFC in 17 female drug-free MDD patients (mean age ± SD, 30.9 ± 6.9 years) and 13 matched control subjects (mean age ± SD, 29.1 ± 6.2 years) and was repeated at 8 weeks following antidepressant treatment.
Results: Comparison of baseline values indicated that there were no significant differences in any of the metabolite ratios (N-acetyl aspartate/creatine [NAA/Cr], myoinositol [Ino]/Cr, and choline [Cho]/Cr) between patients and controls. Significant differences were detected between pre- and post-treatment Ino/Cr ratios (0.67 ± 0.13, 0.58 ± 0.22, P = 0.032, respectively), although there was no difference in NAA/Cr and Cho/Cr ratios.
Conclusion: Although no significant metabolic alterations exist in female patients with drug-naïve first-episode MDD as evaluated on 1H-MRS, an increase in Ino/Cr was observed following 8-week antidepressant treatment. These findings give rise to the possibility that non-neuronal cells, particularly glial cells that are probably damaged, play a role in the action of antidepressant treatment.