Association between neuropeptide Y gene and its receptor Y1 gene and methamphetamine dependence
Article first published online: 14 MAY 2009
© 2009 The Authors. Journal compilation © 2009 Japanese Society of Psychiatry and Neurology
Psychiatry and Clinical Neurosciences
Volume 63, Issue 3, pages 417–422, June 2009
How to Cite
Okahisa, Y., Ujike, H., Kotaka, T., Morita, Y., Kodama, M., Inada, T., Yamada, M., Iwata, N., Iyo, M., Sora, I., Ozaki, N. and Kuroda, S. (2009), Association between neuropeptide Y gene and its receptor Y1 gene and methamphetamine dependence. Psychiatry and Clinical Neurosciences, 63: 417–422. doi: 10.1111/j.1440-1819.2009.01961.x
- Issue published online: 14 MAY 2009
- Article first published online: 14 MAY 2009
- Received 29 October 2008; revised 28 December 2008; accepted 6 January 2009.
- case–control association;
- neuropeptide Y;
- neuropeptide Y receptor type Y1;
- substance abuse
Aims: Neuropeptide Y (NPY) is a 36-amino acid peptide that is widely distributed in the brain, adrenal medulla, and sympathetic nervous system. Several lines of evidence suggest a possible involvement of the NPY system in the physiological effects of several classes of abused substances including alcohol, phencyclidine, cocaine, and marijuana and in endogenous psychosis. Accordingly, it was hypothesized that the NPY system may also be involved in methamphetamine dependence or psychosis.
Methods: The single nucleotide polymorphisms rs16147 of the NPY gene (−485C>T) and rs7687423 of the NPY receptor Y1 (NPY1R) gene were analyzed in 222 patients with methamphetamine dependence and psychosis and 288 age- and gender-matched controls.
Results: Genotypic distribution of the NPY1R gene showed a significant association with methamphetamine dependence and psychosis (P = 0.04), whereas the NPY gene had no significant association with them.
Conclusion: It is possible that genetic variants of the NPY1R gene affect the NPY-NPY receptor type Y1 signaling system in the brain, which may result in susceptibility to methamphetamine dependence or the development of methamphetamine psychosis, but the present findings need to be confirmed on replication.