Correlation between a reduction in Frontal Assessment Battery scores and delusional thoughts in patients with Alzheimer's disease
Version of Record online: 29 APR 2009
© 2009 The Authors. Journal compilation © 2009 Japanese Society of Psychiatry and Neurology
Psychiatry and Clinical Neurosciences
Volume 63, Issue 4, pages 449–454, August 2009
How to Cite
Nagata, T., Ishii, K., Ito, T., Aoki, K., Ehara, Y., Kada, H., Furukawa, H., Tsumura, M., Shinagawa, S., Kasahara, H. and Nakayama, K. (2009), Correlation between a reduction in Frontal Assessment Battery scores and delusional thoughts in patients with Alzheimer's disease. Psychiatry and Clinical Neurosciences, 63: 449–454. doi: 10.1111/j.1440-1819.2009.01968.x
- Issue online: 16 JUL 2009
- Version of Record online: 29 APR 2009
- Received 28 February 2008; revised 4 December 2008; accepted 17 February 2009.
Vol. 63, Issue 5, 704, Version of Record online: 23 SEP 2009
- Alzheimer's disease;
- delusional ideation;
- Frontal Assessment Battery;
Aims: The purpose of the present study was to investigate the relationship between delusional thoughts (delusional ideation or misidentification) and frontal lobe function using the Japanese version of the Frontal Assessment Battery (FAB) bedside screening neuropsychological test in early stage Alzheimer's disease (AD) patients.
Methods: Forty-eight probable AD patients with Mini-Mental State Examination score ≧18 points and a clinical dementia rating score of either 0.5 or 1.0 were divided into two groups based on data obtained from interviews with their caregivers: a delusional thought group (n = 19) and a non-delusional thought group (n = 29). The FAB total and subtest scores were then compared for the two groups.
Results: Significant differences were found between the FAB total (P < 0.01) and subtest scores (similarities, motor series, conflicting instructions; P < 0.05) for the two groups. Multiple regression analysis showed that delusional thought was significantly associated with the FAB total score.
Conclusions: In addition to episodic memory disorders, a reduction in the FAB score may reflect frontal lobe dysfunctions, including executive function, in patients with AD, leading to delusional ideation.