Association between the dysbindin gene (DTNBP1) and cognitive functions in Japanese subjects
Article first published online: 22 MAY 2009
© 2009 The Authors. Journal compilation © 2009 Japanese Society of Psychiatry and Neurology
Psychiatry and Clinical Neurosciences
Volume 63, Issue 4, pages 550–556, August 2009
How to Cite
Hashimoto, R., Noguchi, H., Hori, H., Ohi, K., Yasuda, Y., Takeda, M. and Kunugi, H. (2009), Association between the dysbindin gene (DTNBP1) and cognitive functions in Japanese subjects. Psychiatry and Clinical Neurosciences, 63: 550–556. doi: 10.1111/j.1440-1819.2009.01985.x
- Issue published online: 16 JUL 2009
- Article first published online: 22 MAY 2009
- Received 31 October 2008; revised 3 March 2009; accepted 7 March 2009.
Aim: The dysbindin gene (dystrobrevin binding protein 1: DTNBP1) is a susceptibility gene for schizophrenia. Susceptibility genes for schizophrenia have been hypothesized to mediate liability for the disorder at least partly by influencing cognitive performance. This report investigated the relationship between cognitive function and the dysbindin gene.
Methods: The possible association between a single nucleotide polymorphism (SNP) of DTNBP1 (rs2619539: P1655), which is a risk-independent SNP for schizophrenia in Japanese populations, and memory and IQ was investigated in 70 schizophrenia patients and 165 healthy volunteers in a Japanese population.
Results: This SNP was associated with two memory scales, verbal memory and general memory, on the Wechsler Memory Scale–Revised (WMS-R), and three subcategories of the Wechsler Adult Intelligence Scale–Revised (WAIS-R), vocabulary, similarities and picture completion in healthy subjects. The SNP, however, did not influence either the indices of WMS-R, IQ or subcategories of WAIS-R in schizophrenia patients.
Conclusion: A risk-independent SNP in DTNBP1 may have an impact on cognitive functions such as memory and IQ in healthy subjects.