Both authors contributed equally to this article.
Frontal and cingulate gray matter volume reduction in heroin dependence: Optimized voxel-based morphometry
Article first published online: 15 JUN 2009
© 2009 The Authors. Journal compilation © 2009 Japanese Society of Psychiatry and Neurology
Psychiatry and Clinical Neurosciences
Volume 63, Issue 4, pages 563–568, August 2009
How to Cite
Liu, H., Hao, Y., Kaneko, Y., Ouyang, X., Zhang, Y., Xu, L., Xue, Z. and Liu, Z. (2009), Frontal and cingulate gray matter volume reduction in heroin dependence: Optimized voxel-based morphometry. Psychiatry and Clinical Neurosciences, 63: 563–568. doi: 10.1111/j.1440-1819.2009.01989.x
- Issue published online: 16 JUL 2009
- Article first published online: 15 JUN 2009
- Received 22 December 2008; revised 27 March 2009; accepted 15 April 2009.
- brain imaging;
- gray matter;
- voxel-based morphometry
Aims: Repeated exposure to heroin, a typical opiate, causes neuronal adaptation and may result in anatomical changes in specific brain regions, particularly the frontal and limbic cortices. The volume changes of gray matter (GM) of these brain regions, however, have not been identified in heroin addiction.
Methods: Using structural magnetic resonance imaging and an optimized voxel-based morphometry approach, the GM volume difference between 15 Chinese heroin-dependent and 15 healthy subjects was tested.
Results: Compared to healthy subjects, the heroin-dependent subjects had reduced GM volume in the right prefrontal cortex, left supplementary motor cortex and bilateral cingulate cortices.
Conclusion: Frontal and cingulate atrophy may be involved in the neuropathology of heroin dependence.