Selected testosterone-related diseases in women who have given birth to a child with infantile autism
Version of Record online: 16 JUL 2009
© 2009 The Authors. Journal compilation © 2009 Japanese Society of Psychiatry and Neurology
Psychiatry and Clinical Neurosciences
Volume 63, Issue 4, pages 586–590, August 2009
How to Cite
Mouridsen, S. E., Rich, B. and Isager, T. (2009), Selected testosterone-related diseases in women who have given birth to a child with infantile autism. Psychiatry and Clinical Neurosciences, 63: 586–590. doi: 10.1111/j.1440-1819.2009.01997.x
- Issue online: 16 JUL 2009
- Version of Record online: 16 JUL 2009
- Received 3 December 2008; revised 12 March 2009; accepted 23 April 2009.
- androgen theory of autism;
- infantile autism;
Aim: The objective of the current study was to compare the prevalence of three testosterone-related cancer diseases in the mothers of 111 individuals diagnosed as children with infantile autism (IA) with a matched comparison group of mothers of 330 children from the general population.
Method: All mothers were screened through the nationwide Danish National Hospital Register. We inquired about breast-, uterine-, and ovarian cancer diseases during an observation period of 27 years.
Results: At follow up a similar proportion of case and control mothers had a diagnosis of any cancer disease: 6.3% vs 8.5%. In addition, no single cancer disease was significantly more frequent among mothers of children with IA.
Conclusion: Our study provides no support for an (eventually androgen-mediated) increased rate of cancer in mothers of persons with IA.