Psychogeriatrics and old age psychiatry
Distribution of neurofibrillary tangles in diffuse neurofibrillary tangles with calcification
Article first published online: 30 JUN 2009
© 2009 The Authors. Journal compilation © 2009 Japanese Society of Psychiatry and Neurology
Psychiatry and Clinical Neurosciences
Volume 63, Issue 5, pages 646–651, October 2009
How to Cite
Ukai, K., Shibayama, H., Ishihara, R. and Ozaki, N. (2009), Distribution of neurofibrillary tangles in diffuse neurofibrillary tangles with calcification. Psychiatry and Clinical Neurosciences, 63: 646–651. doi: 10.1111/j.1440-1819.2009.02000.x
Distribution of neurofibrillary tangles
- Issue published online: 23 SEP 2009
- Article first published online: 30 JUN 2009
- Received 20 August 2008; revised 25 April 2009; accepted 30 April 2009.
- diffuse neurofibrillary tangles with calcification (DNTC);
- distribution of neurofibrillary tangles;
- Kosaka–Shibayama disease;
- neurofibrillary tangles (NFT)
Aims: In this study, the appearance and distribution of neurofibrillary tangles (NFT) in diffuse neurofibrillary tangles with calcification (DNTC) were investigated neuropathologically in order to elucidate the detailed distribution pattern in this disease.
Methods: The distribution of NFT in six cases neuropathologically diagnosed as DNTC (two men and four women) was studied using Gallyas–Braak silver stain. The age at death ranged from 56 to 73, with an average of 63.5 ± 7.5 years.
Results: NFT were seen throughout the cerebral cortex, and were especially marked in the temporal and limbic cortices. The distribution pattern of NFT in the limbic lobe was similar to that in Alzheimer's disease as reported in the previous studies. In the temporal lobe, more NFT were distributed in the anterior than in the posterior area, which was confirmed in all six cases. The temporal pole showed the highest density of NFT including ghost tangles.
Conclusions: The diffuse appearance of NFT in the cerebral cortex with the highest severity in the temporal pole was found to be a neuropathological characteristic of DNTC.