No association between polymorphism in tyrosine hydroxylase and personality traits in healthy Japanese subjects
Article first published online: 1 FEB 2010
© 2010 The Authors. Journal compilation © 2010 Japanese Society of Psychiatry and Neurology
Psychiatry and Clinical Neurosciences
Volume 64, Issue 2, pages 196–198, April 2010
How to Cite
Tsuchimine, S., Yasui-Furukori, N., Kaneda, A., Saito, M., Nakagami, T., Sugawara, N. and Kaneko, S. (2010), No association between polymorphism in tyrosine hydroxylase and personality traits in healthy Japanese subjects. Psychiatry and Clinical Neurosciences, 64: 196–198. doi: 10.1111/j.1440-1819.2010.02061.x
- Issue published online: 24 MAR 2010
- Article first published online: 1 FEB 2010
- Received 5 June 2009; revised 30 November 2009; accepted 6 December 2009.
- Temperament and Character Inventory;
- tyrosine hydroxylase
The aim of the present study was to investigate whether there is an association between the (TCAT)n repeat polymorphism in the tyrosine hydroxylase (TH) gene and personality. The (TCAT)n repeat polymorphism in the TH gene was genotyped in 898 healthy Japanese subjects. Personality traits were evaluated using the Temperament and Character Inventory (TCI). There was no significant difference in the TCI scores of subjects with and without the T9 allele. Furthermore, no significant association was found between each genotype and the TCI scores, even when the TCI scores were compared with the homozygous genotype. These findings suggest that the (TCAT)n repeat polymorphism in the TH gene does not contribute to the personality traits evaluated on the TCI in healthy Japanese subjects.