Anti-Borna disease virus antibody responses in psychiatric patients: Long-term follow up
Version of Record online: 8 APR 2010
© 2010 The Authors. Journal compilation © 2010 Japanese Society of Psychiatry and Neurology
Psychiatry and Clinical Neurosciences
Volume 64, Issue 3, pages 255–261, June 2010
How to Cite
Heinrich, A. and Adamaszek, M. (2010), Anti-Borna disease virus antibody responses in psychiatric patients: Long-term follow up. Psychiatry and Clinical Neurosciences, 64: 255–261. doi: 10.1111/j.1440-1819.2010.02073.x
- Issue online: 18 MAY 2010
- Version of Record online: 8 APR 2010
- Received 28 April 2009; revised 30 December 2009; accepted 13 January 2010.
- affective disorders;
- Borna disease virus;
- indirect immunofluorescence;
Aim: Data suggesting a pathogenetic role for Borna disease virus (BDV) in neuropsychiatric diseases are still inconclusive and it is unknown whether humans become persistently infected or clear the virus infection. The aim of the present study was therefore to investigate long-term BDV-specific antibody responses in psychiatric patients in order to gain new insights into human BDV infection and its pathogenicity.
Methods: BDV-specific antibody titers and associations with clinical conditions were studied retrospectively in 94 seropositive patients with schizophrenia (n = 46), affective disorders (n = 19) and other psychiatric disorders (n = 29) who had been repeatedly tested for the presence of BDV-specific antibodies on indirect immunofluorescence assay between 1985 and 2006. Long-term titer dynamics were studied in 46 patients followed up for a period of >36 months.
Results: A total of 25 of these 46 patients (54.3%) had persistent seropositivity, whereas seroreversion from positive to negative was observed in 21 (45.7%). Patients in the early course of schizophrenia had lower antibody titers compared to patients in the advanced course (P = 0.017), while a higher proportion of patients in the early course had titer increases (P < 0.05). There were no significant differences in antibody titers between patient subgroups with clinically stable and acute psychiatric disorders.
Conclusion: Persistent seropositivity in a subgroup of psychiatric patients in the long-term analysis suggests chronic BDV infection in humans.