Plasma BDNF and tPA are associated with late-onset geriatric depression

Authors

  • Yanyan Shi MD,

    1. Department of Psychiatry, Nanjing Brain Hospital Affiliated to Nanjing Medical University and
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  • Jiayong You MD,

    1. Department of Psychiatry, Nanjing Brain Hospital Affiliated to Nanjing Medical University and
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  • Yonggui Yuan MD, PhD,

    Corresponding author
    1. Department of Psychiatry, Nanjing Brain Hospital Affiliated to Nanjing Medical University and
    2. Department of Neuropsychiatry, Affiliated ZhongDa Hospital of Southeast University, Nanjing, China
      Yonggui Yuan, MD, Department of Psychiatry, Nanjing Brain Hospital affiliated to Nanjing Medical University, No. 264, Guangzhou Road, Nanjing 210029, China. Email: yygylh2000@sina.com.cn
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  • Xiangrong Zhang MD, PhD,

    1. Department of Neuropsychiatry, Affiliated ZhongDa Hospital of Southeast University, Nanjing, China
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  • Hailin Li MD,

    1. Department of Psychiatry, Nanjing Brain Hospital Affiliated to Nanjing Medical University and
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  • Gang Hou MD

    1. Department of Psychiatry, Nanjing Brain Hospital Affiliated to Nanjing Medical University and
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Yonggui Yuan, MD, Department of Psychiatry, Nanjing Brain Hospital affiliated to Nanjing Medical University, No. 264, Guangzhou Road, Nanjing 210029, China. Email: yygylh2000@sina.com.cn

Abstract

Aims:  Studies in the recent decade have shown that brain-derived neurotrophic factor (BDNF) may play an important role in the pathogenesis of major depressive disorder (MDD). Tissue-type plasminogen activator (tPA) has been implicated in the control of the direction of BDNF action. The aim of the study was therefore to investigate the changes of BDNF/tPA levels and their clinical meanings in geriatric depression.

Methods:  Plasma BDNF and tPA levels were measured in late-onset geriatric depression (LGD) before treatment (n = 24) and after 6 weeks of antidepressant treatment (n = 24) compared with control subjects (n = 30) using enzyme-linked immunosorbent assay. The severity of depression was assessed with the Hamilton Depression Rating Scale.

Results:  Baseline plasma BDNF and tPA levels were significantly lower in LGD patients compared to controls (P = 0.037 and P = 0.000, respectively). There was a heightening tendency of plasma BDNF level after treatment.

Conclusions:  Plasma BDNF and tPA levels are associated with LGD. The complex mechanism of BDNF and tPA in LGD should be further explored in future studies.

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