Plasma BDNF and tPA are associated with late-onset geriatric depression
Article first published online: 18 MAY 2010
© 2010 The Authors. Journal compilation © 2010 Japanese Society of Psychiatry and Neurology
Psychiatry and Clinical Neurosciences
Volume 64, Issue 3, pages 249–254, June 2010
How to Cite
Shi, Y., You, J., Yuan, Y., Zhang, X., Li, H. and Hou, G. (2010), Plasma BDNF and tPA are associated with late-onset geriatric depression. Psychiatry and Clinical Neurosciences, 64: 249–254. doi: 10.1111/j.1440-1819.2010.02074.x
- Issue published online: 18 MAY 2010
- Article first published online: 18 MAY 2010
- Received 16 April 2009; revised 1 December 2009; accepted 22 January 2010.
- brain-derived neurotrophic factor;
- late-onset geriatric depression;
- tissue-type plasminogen activator
Aims: Studies in the recent decade have shown that brain-derived neurotrophic factor (BDNF) may play an important role in the pathogenesis of major depressive disorder (MDD). Tissue-type plasminogen activator (tPA) has been implicated in the control of the direction of BDNF action. The aim of the study was therefore to investigate the changes of BDNF/tPA levels and their clinical meanings in geriatric depression.
Methods: Plasma BDNF and tPA levels were measured in late-onset geriatric depression (LGD) before treatment (n = 24) and after 6 weeks of antidepressant treatment (n = 24) compared with control subjects (n = 30) using enzyme-linked immunosorbent assay. The severity of depression was assessed with the Hamilton Depression Rating Scale.
Results: Baseline plasma BDNF and tPA levels were significantly lower in LGD patients compared to controls (P = 0.037 and P = 0.000, respectively). There was a heightening tendency of plasma BDNF level after treatment.
Conclusions: Plasma BDNF and tPA levels are associated with LGD. The complex mechanism of BDNF and tPA in LGD should be further explored in future studies.