Duration of untreated illness and antidepressant fluvoxamine response in major depressive disorder
Article first published online: 18 MAY 2010
© 2010 The Authors. Journal compilation © 2010 Japanese Society of Psychiatry and Neurology
Psychiatry and Clinical Neurosciences
Volume 64, Issue 3, pages 268–273, June 2010
How to Cite
Okuda, A., Suzuki, T., Kishi, T., Yamanouchi, Y., Umeda, K., Haitoh, H., Hashimoto, S., Ozaki, N. and Iwata, N. (2010), Duration of untreated illness and antidepressant fluvoxamine response in major depressive disorder. Psychiatry and Clinical Neurosciences, 64: 268–273. doi: 10.1111/j.1440-1819.2010.02091.x
- Issue published online: 18 MAY 2010
- Article first published online: 18 MAY 2010
- Received 29 May 2009; revised 16 January 2010; accepted 8 March 2010.
- duration of untreated illness;
- early intervention;
- major depressive disorder;
- treatment outcome
Aims: The aim of this study was to analyze the relation between treatment response and the duration of untreated illness (DUI) in 133 outpatients with the first major depressive disorder (MDD) episode.
Methods: A logistic regression was performed with DUI, sex, age at onset, and score for 17 items on the Hamilton Depression Rating Scale at the time of start of fluvoxamine treatment as the explanatory variables, and the response and the remission as the outcome variables.
Results: Regression analysis showed significant association between the response and DUI (P < 0.0001), and between the remission and DUI (P < 0.0001), respectively. The remission rate gradually decreased with longer DUI.
Conclusion: Early treatment of first depressive episodes is important because a shorter DUI implied better remission outcomes.