Reduced gray matter volume of dorsal cingulate cortex in patients with obsessive–compulsive disorder: A voxel-based morphometric study
Version of Record online: 28 SEP 2010
© 2010 The Authors. Psychiatry and Clinical Neurosciences © 2010 Japanese Society of Psychiatry and Neurology
Psychiatry and Clinical Neurosciences
Volume 64, Issue 5, pages 541–547, October 2010
How to Cite
Matsumoto, R., Ito, H., Takahashi, H., Ando, T., Fujimura, Y., Nakayama, K., Okubo, Y., Obata, T., Fukui, K. and Suhara, T. (2010), Reduced gray matter volume of dorsal cingulate cortex in patients with obsessive–compulsive disorder: A voxel-based morphometric study. Psychiatry and Clinical Neurosciences, 64: 541–547. doi: 10.1111/j.1440-1819.2010.02125.x
- Issue online: 28 SEP 2010
- Version of Record online: 28 SEP 2010
- Received 30 April 2009; revised 26 April 2010; accepted 26 June 2010.
- cingulate cortex;
- magnetic resonance imaging;
- obsessive–compulsive disorder;
- voxel-based morphometry
Aims: Previous morphometric studies using magnetic resonance imaging (MRI) have revealed structural brain abnormalities in obsessive–compulsive disorder (OCD). The aim of the present study was to investigate the alterations in brain structure of patients with OCD using a voxel-based morphometry (VBM) method.
Methods: Sixteen patients with OCD free of comorbid major depression, and 32 sex- and age-matched healthy subjects underwent MRI using a 1.5-T MR scanner. OCD severity was assessed with the Yale–Brown Obsessive–Compulsive Scale (mean ± SD: 22 ± 7.6; range: 7–32). MR images were spatially normalized and segmented using the VBM5 package (http://dbm.neuro.uni-jena.de/vbm/). Statistical analysis was performed using statistical parametric mapping software.
Results: Significant reductions in regional gray matter volume were detected in the left caudal anterior cingulate cortex and right dorsal posterior cingulate cortex in the patients with OCD as compared to healthy controls (uncorrected, P < 0.001). No significant differences in white matter volumes were observed in any brain regions of the patients. No significant correlation between Yale–Brown Obsessive–Compulsive Scale score and regional gray matter or white matter volume was observed.
Conclusions: Regional gray matter alteration in the dorsal cingulate cortex, which is suggested to play a role in non-emotional cognitive processes, may be related to the pathophysiology in OCD.