Serum ghrelin is inversely associated with cognitive function in a sample of non-demented elderly
Article first published online: 28 OCT 2010
© 2010 The Authors. Psychiatry and Clinical Neurosciences © 2010 Japanese Society of Psychiatry and Neurology
Psychiatry and Clinical Neurosciences
Volume 64, Issue 6, pages 608–611, December 2010
How to Cite
Spitznagel, M. B., Benitez, A., Updegraff, J., Potter, V., Alexander, T., Glickman, E. and Gunstad, J. (2010), Serum ghrelin is inversely associated with cognitive function in a sample of non-demented elderly. Psychiatry and Clinical Neurosciences, 64: 608–611. doi: 10.1111/j.1440-1819.2010.02145.x
- Issue published online: 25 NOV 2010
- Article first published online: 28 OCT 2010
- Received 9 September 2009; revised 23 July 2010; accepted 25 August 2010.
- biological psychiatry;
- interdisciplinary collaboration;
- old age psychiatry;
- medicine and primary care;
Aim: The orexigenic hormone, ghrelin, is linked to learning and memory in animal studies. No previous study has investigated whether cognition is related to ghrelin in the non-demented elderly.
Methods: Thirty-five older adults underwent neuropsychological testing and fasting blood draw with subsequent serum ghrelin quantification.
Results: Ghrelin was negatively correlated with several cognitive domains, including verbal memory, working memory, and naming.
Conclusion: Areas of cognition associated with ghrelin level were similar to the pattern of deficits observed in early Alzheimer's disease. Findings suggest a potential moderational role of ghrelin in pathological cognitive decline. Further work investigating mechanisms is needed.