Age-specific prevalence of metabolic syndrome in Italian patients with bipolar disorder
Article first published online: 26 JAN 2011
© 2011 The Authors. Psychiatry and Clinical Neurosciences © 2011 Japanese Society of Psychiatry and Neurology
Psychiatry and Clinical Neurosciences
Volume 65, Issue 1, pages 47–54, February 2011
How to Cite
Salvi, V., D'Ambrosio, V., Rosso, G., Bogetto, F. and Maina, G. (2011), Age-specific prevalence of metabolic syndrome in Italian patients with bipolar disorder. Psychiatry and Clinical Neurosciences, 65: 47–54. doi: 10.1111/j.1440-1819.2010.02160.x
- Issue published online: 26 JAN 2011
- Article first published online: 26 JAN 2011
- Received 18 November 2009; revised 8 October 2010; accepted 14 October 2010.
- age groups;
- bipolar disorder;
- metabolic syndrome;
- physical exercise
Aim: Metabolic syndrome (MetS) is highly prevalent in patients with bipolar disorder (BD). Little research has evaluated the risk profile of MetS and cardiovascular disease in different gender and age groups in these patients. Our aim is to evaluate the prevalence of MetS in Italian patients with BD stratified by gender and age, and to determine the correlates of MetS.
Methods: Subjects with BD were included and stratified by sex and age according to the following age groups: <30; 30–39; 40–49; 50–59; ≥60 years. Socio-demographic and clinical characteristics, lifestyle information, and comorbidity for cardiovascular diseases and diabetes were collected. MetS was diagnosed according to National Cholesterol Education Program Adult Treatment Panel III modified criteria.
Results: MetS was evaluated in 200 patients, with a prevalence of 26.5%. Men had higher rates of hypertension and hypertriglyceridemia, women had more abdominal obesity. Women had a peak of prevalence in the ≥60 years group, while men displayed high rates even in the young age groups. In young patients, MetS was associated with Cluster B personality disorders and less physical exercise.
Conclusion: Our paper highlights the importance of evaluating MetS even in young patients with bipolar disorder, especially males. The strong association with lack of physical exercise suggests that the implementation of healthy behaviors might be relevant in order to prevent MetS and future adverse cardiovascular outcomes.