Reduced central white matter volume in autism: Implications for long-range connectivity
Article first published online: 22 DEC 2010
© 2010 The Authors. Psychiatry and Clinical Neurosciences © 2010 Japanese Society of Psychiatry and Neurology
Psychiatry and Clinical Neurosciences
Volume 65, Issue 1, pages 98–101, February 2011
How to Cite
Jou, R. J., Mateljevic, N., Minshew, N. J., Keshavan, M. S. and Hardan, A. Y. (2011), Reduced central white matter volume in autism: Implications for long-range connectivity. Psychiatry and Clinical Neurosciences, 65: 98–101. doi: 10.1111/j.1440-1819.2010.02164.x
- Issue published online: 26 JAN 2011
- Article first published online: 22 DEC 2010
- Received 26 April 2010; revised 18 October 2010; accepted 27 October 2010.
- child and adolescent psychiatry;
- magnetic resonance imaging
Cortical and central white matter (WM) volumes were measured to assess short- and long-range connectivity in autism, respectively. Subjects included 23 boys with autism and 23 matched controls, all without intellectual disability. Magnetic resonance imaging data obtained at 1.5 T were analyzed using BRAINS2 software (University of Iowa, Iowa City, IA, USA). Central WM volume was quantified by subtracting cortical from supratentorial WM volumes. Reduced central WM volume was observed in the autism group. IQ was higher in controls with no observed correlations between WM volumes and IQ. This preliminary evidence of reduced central WM volume in autism suggests abnormal long-range connectivity.