Chronic repetitive transcranial magnetic stimulation increases hippocampal neurogenesis in rats
Article first published online: 26 JAN 2011
© 2011 The Authors. Psychiatry and Clinical Neurosciences © 2011 Japanese Society of Psychiatry and Neurology
Psychiatry and Clinical Neurosciences
Volume 65, Issue 1, pages 77–81, February 2011
How to Cite
Ueyama, E., Ukai, S., Ogawa, A., Yamamoto, M., Kawaguchi, S., Ishii, R. and Shinosaki, K. (2011), Chronic repetitive transcranial magnetic stimulation increases hippocampal neurogenesis in rats. Psychiatry and Clinical Neurosciences, 65: 77–81. doi: 10.1111/j.1440-1819.2010.02170.x
- Issue published online: 26 JAN 2011
- Article first published online: 26 JAN 2011
- Received 30 June 2010; revised 3 November 2010; accepted 14 November 2010.
- transcranial magnetic stimulation
Aim: While the underlying therapeutic mechanisms of repetitive transcranial magnetic stimulation (rTMS) treatment for depression remain unclear, recent animal studies have suggested that hippocampal neurogenesis might be required for the effects of antidepressant treatments including antidepressant drugs and electroconvulsive therapy. The aim of this study was to examine chronic rTMS effects on hippocampal neurogenesis in rats.
Methods: Using a 70-mm figure-of-eight coil, the stimulating parameters were set to 25 Hz and 70% of the rTMS device's maximum power. For 14 consecutive days, bromodeoxyuridine (BrdU) and 1000 pulses of rTMS were administered daily. Cell proliferation in the dentate gyrus was examined with immunohistochemistry.
Results: In the rTMS-treated group, BrdU-positive cells were significantly increased in the dentate gyrus.
Conclusion: Our results suggest that hippocampal neurogenesis might be involved in the antidepressant effects of chronic rTMS.