Connectivity between mitochondrial functions and psychiatric disorders
Article first published online: 17 MAR 2011
© 2011 The Authors. Psychiatry and Clinical Neurosciences © 2011 Japanese Society of Psychiatry and Neurology
Psychiatry and Clinical Neurosciences
Volume 65, Issue 2, pages 130–141, March 2011
How to Cite
Hroudová, J. and Fišar, Z. (2011), Connectivity between mitochondrial functions and psychiatric disorders. Psychiatry and Clinical Neurosciences, 65: 130–141. doi: 10.1111/j.1440-1819.2010.02178.x
- Issue published online: 17 MAR 2011
- Article first published online: 17 MAR 2011
- Received 1 June 2010; revised 30 September 2010; accepted 29 November 2010.
- mood disorders;
- mood stabilizers;
- mitochondrial DNA
Mitochondria provide most of the energy production in cells. They are involved in the regulation of free radicals, calcium buffering, and redox signaling and take part in the intrinsic pathway of apoptosis. Mutations or polymorphisms of mitochondrial DNA, mitochondria-mediated oxidative stress, decrease of adenosine triphosphate production, changes of intracellular calcium and oxidative stress are concerned in various diseases. There is increasing evidence that impaired functions of mitochondria are associated with mood disorders. It is suggested that disturbed energetic metabolism and/or reactive oxygen species production take part in the pathophysiology of mood disorders and could participate in the therapeutic effects or side-effects of antidepressants and mood stabilizers.