Distress due to lithium-induced polyuria: Exploratory study
Article first published online: 16 MAY 2011
© 2011 The Authors. Psychiatry and Clinical Neurosciences © 2011 Japanese Society of Psychiatry and Neurology
Psychiatry and Clinical Neurosciences
Volume 65, Issue 4, pages 386–388, June 2011
How to Cite
Pradhan, B. K., Chakrabarti, S., Irpati, A. S. and Bhardwaj, R. (2011), Distress due to lithium-induced polyuria: Exploratory study. Psychiatry and Clinical Neurosciences, 65: 386–388. doi: 10.1111/j.1440-1819.2011.02214.x
- Issue published online: 20 JUN 2011
- Article first published online: 16 MAY 2011
- Received 6 July 2010; revised 23 February 2011; accepted 5 March 2011.
Lithium-induced polyuria, although common, often goes unrecognized. The purpose of the present study was therefore to investigate the complaints of polyuria, and distress and functional impairment associated with polyuria, in 56 patients with bipolar disorder on long-term lithium treatment. All participants underwent 24-h urine collection, and renal function tests. Polyuria (24-h urine volume > 3 L) was found in 70% of subjects. Unless directly enquired about, polyuria was underreported. Impairment in work and daily routine due to increased urine output/frequency was associated with 24-h urine volumes. Polyuria is a highly prevalent, distressing and impairing side-effect of long-term lithium treatment, requiring due attention.