Abnormal sensitivity to negative feedback in late-life depression
Article first published online: 16 MAY 2011
© 2011 The Authors. Psychiatry and Clinical Neurosciences © 2011 Japanese Society of Psychiatry and Neurology
Psychiatry and Clinical Neurosciences
Volume 65, Issue 4, pages 333–340, June 2011
How to Cite
von Gunten, A., Herrmann, F. R., Elliott, R. and Duc, R. (2011), Abnormal sensitivity to negative feedback in late-life depression. Psychiatry and Clinical Neurosciences, 65: 333–340. doi: 10.1111/j.1440-1819.2011.02215.x
- Issue published online: 20 JUN 2011
- Article first published online: 16 MAY 2011
- Received 1 December 2009; revised 8 February 2011; accepted 4 March 2011.
- cognitive mechanisms;
Aims: The purpose of the present study was to probe sensitivity to potentially misleading negative feedback on cognitive tasks as a possible mechanism of cognitive impairment in elderly patients with mild depression.
Methods: A total of 22 mildly depressed elderly subjects were compared to 22 healthy controls, using a computerized Tower-of-London task.
Results: Failure and magnitude of failure were significantly worse after negative but not positive feedback. Depression predicted failure after negative feedback but not the magnitude of failure. Neither failure nor magnitude of failure increased as a consequence of repeated negative feedback.
Conclusions: Altered sensitivity to negative feedback occurs in mild late-life unipolar depression and may represent a subtle context-specific phenomenon.