Midbrain volume increase in patients with panic disorder
Article first published online: 20 JUN 2011
© 2011 The Authors. Psychiatry and Clinical Neurosciences © 2011 Japanese Society of Psychiatry and Neurology
Psychiatry and Clinical Neurosciences
Volume 65, Issue 4, pages 365–373, June 2011
How to Cite
Fujiwara, A., Yoshida, T., Otsuka, T., Hayano, F., Asami, T., Narita, H., Nakamura, M., Inoue, T. and Hirayasu, Y. (2011), Midbrain volume increase in patients with panic disorder. Psychiatry and Clinical Neurosciences, 65: 365–373. doi: 10.1111/j.1440-1819.2011.02219.x
- Issue published online: 20 JUN 2011
- Article first published online: 20 JUN 2011
- Received 10 September 2010; revised 14 February 2011; accepted 26 March 2011.
- magnetic resonance imaging;
- panic disorder;
- region of interest
Aim: Although recent studies suggest abnormalities of the cerebral cortex, limbic structures, and brain stem regions in panic disorder (PD), the extent to which the midbrain is associated with PD pathophysiology is unclear. The aim of this study was to investigate structural abnormalities of the midbrain using magnetic resonance imaging and to determine if there is a clinical correlation between midbrain volume and clinical measurements in patients with PD.
Methods: Thirty-eight patients with PD (PD group) and 38 healthy controls (HC group) participated in this study. The midbrain was measured with a manual tracing method with high spatial resolution magnetic resonance imaging. The Panic Disorder Severity Scale and Global Assessment of Functioning were used to examine the correlation between volume abnormality and clinical symptoms and functioning in the PD group.
Results: Relative midbrain volume was larger in the PD group than in the HC group. The relative volume of the dorsal midbrain was larger in the PD group, while the volume of the ventral midbrain was not. We found a significant positive correlation between relative dorsal midbrain volume and total Panic Disorder Severity Scale score, and a significant negative correlation between relative dorsal midbrain volume and Global Assessment of Functioning score in the PD group.
Conclusions: Our findings suggest that the dorsal midbrain is associated with PD pathophysiology. The midbrain volume increase may reflect PD severity.