Sexually dimorphic distribution of orbitofrontal sulcogyral pattern in schizophrenia
Article first published online: 18 AUG 2011
© 2011 The Authors. Psychiatry and Clinical Neurosciences © 2011 Japanese Society of Psychiatry and Neurology
Psychiatry and Clinical Neurosciences
Volume 65, Issue 5, pages 483–489, August 2011
How to Cite
Uehara-Aoyama, K., Nakamura, M., Asami, T., Yoshida, T., Hayano, F., Roppongi, T., Fujiwara, A., Inoue, T., Shenton, M. E. and Hirayasu, Y. (2011), Sexually dimorphic distribution of orbitofrontal sulcogyral pattern in schizophrenia. Psychiatry and Clinical Neurosciences, 65: 483–489. doi: 10.1111/j.1440-1819.2011.02229.x
- Issue published online: 18 AUG 2011
- Article first published online: 18 AUG 2011
- Received 28 September 2010; revised 2 April 2011; accepted 30 April 2011.
- orbitofrontal cortex;
- sulcogyral pattern;
Aim: The sulcogyral pattern of the orbitofrontal cortex (OFC) is characterized by a remarkable inter-individual variability that likely reflects neurobehavioral traits and genetic aspects of neurodevelopment. The aim of the present study was to evaluate the OFC sulcogyral pattern of patients with schizophrenia (SZ) and healthy controls (HC) to determine group differences in OFC sulcogyral pattern as well as gender differences between groups.
Methods: Forty-seven SZ patients (M/F, 23/24) and forty-seven HC (M/F, 17/30), matched on age and gender, were analyzed using magnetic resonance imaging. The sulcogyral pattern was classified into type I, II, or III based on the guidelines set by Chiavaras and Petrides in a previous paper. Chi-squared analysis was used to investigate group and gender differences in the sulcogyral pattern distribution, and categorical regression was used to explore clinical correlations.
Results: The distribution of OFC sulcogyral pattern in HC replicated the results found in the previous study (left, χ2 = 0.02, P = 0.989; right, χ2 = 0.97, P = 0.616), in that there were no gender differences. Moreover, the distribution in SZ-M was in accordance with that in the previous study (left, χ2 = 1.59, P = 0.451; right, χ2 = 0.14, P = 0.933). Additionally, within SZ-M, patients with the type III pattern had a higher total positive and negative syndrome scale score (β = 0.902, F = 14.75, P = 0.001). In contrast, the distribution in the right hemisphere in the SZ-F group differed significantly from that observed in SZ-M (χ2 = 6.017, P = 0.046), but did not differ from HC (χ2 = 2.557, P = 0.110).
Conclusion: OFC sulcogyral pattern is altered in SZ-M but not in SZ-F, possibly reflecting gender differences in early neurodevelopment.