Sexually dimorphic distribution of orbitofrontal sulcogyral pattern in schizophrenia

Authors

  • Kumi Uehara-Aoyama MD,

    1. Department of Psychiatry, Yokohama City University, Yokohama
    2. Department of Clinical Research, Kanagawa Psychiatric Center, Kanagawa, Japan
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  • Motoaki Nakamura MD, PhD,

    1. Department of Psychiatry, Yokohama City University, Yokohama
    2. Department of Clinical Research, Kanagawa Psychiatric Center, Kanagawa, Japan
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  • Takeshi Asami MD, PhD,

    1. Department of Psychiatry, Yokohama City University, Yokohama
    2. Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School
    3. Clinical Neuroscience Division, Laboratory of Neuroscience, VA Boston Healthcare System, Brockton and Harvard Medical School, Massachusetts, USA
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  • Takeshi Yoshida MD, PhD,

    1. Department of Psychiatry, Yokohama City University, Yokohama
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  • Fumi Hayano PhD,

    1. Department of Psychiatry, Yokohama City University, Yokohama
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  • Tomohide Roppongi MD, PhD,

    1. Department of Psychiatry, Yokohama City University, Yokohama
    2. Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School
    3. Clinical Neuroscience Division, Laboratory of Neuroscience, VA Boston Healthcare System, Brockton and Harvard Medical School, Massachusetts, USA
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  • Akiko Fujiwara MD,

    1. Department of Psychiatry, Yokohama City University, Yokohama
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  • Tomio Inoue MD, PhD,

    1. Department of Psychiatry, Yokohama City University, Yokohama
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  • Martha E. Shenton PhD,

    1. Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School
    2. Clinical Neuroscience Division, Laboratory of Neuroscience, VA Boston Healthcare System, Brockton and Harvard Medical School, Massachusetts, USA
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  • Yoshio Hirayasu MD, PhD

    Corresponding author
    1. Department of Psychiatry, Yokohama City University, Yokohama
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Yoshio Hirayasu, MD, PhD, Department of Psychiatry, Yokohama City University, Yokohama 236-0004, Japan. Email: hirayasu@yokohama-cu.ac.jp

Abstract

Aim:  The sulcogyral pattern of the orbitofrontal cortex (OFC) is characterized by a remarkable inter-individual variability that likely reflects neurobehavioral traits and genetic aspects of neurodevelopment. The aim of the present study was to evaluate the OFC sulcogyral pattern of patients with schizophrenia (SZ) and healthy controls (HC) to determine group differences in OFC sulcogyral pattern as well as gender differences between groups.

Methods:  Forty-seven SZ patients (M/F, 23/24) and forty-seven HC (M/F, 17/30), matched on age and gender, were analyzed using magnetic resonance imaging. The sulcogyral pattern was classified into type I, II, or III based on the guidelines set by Chiavaras and Petrides in a previous paper. Chi-squared analysis was used to investigate group and gender differences in the sulcogyral pattern distribution, and categorical regression was used to explore clinical correlations.

Results:  The distribution of OFC sulcogyral pattern in HC replicated the results found in the previous study (left, χ2 = 0.02, P = 0.989; right, χ2 = 0.97, P = 0.616), in that there were no gender differences. Moreover, the distribution in SZ-M was in accordance with that in the previous study (left, χ2 = 1.59, P = 0.451; right, χ2 = 0.14, P = 0.933). Additionally, within SZ-M, patients with the type III pattern had a higher total positive and negative syndrome scale score (β = 0.902, F = 14.75, P = 0.001). In contrast, the distribution in the right hemisphere in the SZ-F group differed significantly from that observed in SZ-M (χ2 = 6.017, P = 0.046), but did not differ from HC (χ2 = 2.557, P = 0.110).

Conclusion:  OFC sulcogyral pattern is altered in SZ-M but not in SZ-F, possibly reflecting gender differences in early neurodevelopment.

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