Hemispheric asymmetry in non-linear interdependence of EEG in post-traumatic stress disorder
Article first published online: 21 FEB 2012
© 2012 The Authors. Psychiatry and Clinical Neurosciences © 2012 Japanese Society of Psychiatry and Neurology
Psychiatry and Clinical Neurosciences
Volume 66, Issue 2, pages 87–96, March 2012
How to Cite
Kim, J., Chae, J.-H., Ko, H.-k., Latchoumane, C.-F. V., Banerjee, A., Mandell, D. J., Hoven, C. W. and Jeong, J. (2012), Hemispheric asymmetry in non-linear interdependence of EEG in post-traumatic stress disorder. Psychiatry and Clinical Neurosciences, 66: 87–96. doi: 10.1111/j.1440-1819.2011.02300.x
- Issue published online: 21 FEB 2012
- Article first published online: 21 FEB 2012
- Received 5 September 2009; revised 4 May 2011; accepted 12 August 2011.
- non-linear interdependence;
- post-traumatic stress disorder
Aim: While volumetric and metabolic imaging on post-traumatic stress disorder (PTSD) patients has been intensively performed, few studies using electroencephalograms (EEG) have been done as yet. The aim of the present study was to investigate abnormalities in functional connectivity of cortical networks in PTSD.
Methods: Non-linear interdependence (NI), a measure of bidirectional, non-linear information transmission between two time series, was used. Resting EEG were recorded for 18 PTSD patients and 18 sex-matched healthy subjects on 16 channels with their eyes closed.
Results: The NI patterns in PTSD patients were hemisphere asymmetric: an increase in NI in the fronto-parieto-temporal regions of the left hemisphere (F7, F3, T3, C3, T5 and P3) and a decrease in the fronto-parieto-occipital regions of the right hemisphere (F4, C4, P4 and O2). The non-linearity of NI in EEG, estimated from the surrogate data method, exhibited an increase in the PTSD patients as compared with that of healthy subjects, particularly in the left hemispheric cortex.
Conclusion: Abnormal functional connectivity in PTSD can be assessed using NI, a measure of multi-channel EEG.