Relationships between exploratory eye movement dysfunction and clinical symptoms in schizophrenia
Article first published online: 28 FEB 2012
© 2012 The Authors. Psychiatry and Clinical Neurosciences © 2012 Japanese Society of Psychiatry and Neurology
Psychiatry and Clinical Neurosciences
Volume 66, Issue 3, pages 187–194, April 2012
How to Cite
Suzuki, M., Takahashi, S., Matsushima, E., Tsunoda, M., Kurachi, M., Okada, T., Hayashi, T., Ishii, Y., Morita, K., Maeda, H., Katayama, S., Otsuka, T., Hirayasu, Y., Sekine, M., Okubo, Y., Motoshita, M., Ohta, K., Uchiyama, M. and Kojima, T. (2012), Relationships between exploratory eye movement dysfunction and clinical symptoms in schizophrenia. Psychiatry and Clinical Neurosciences, 66: 187–194. doi: 10.1111/j.1440-1819.2011.02314.x
- Issue published online: 23 MAR 2012
- Article first published online: 28 FEB 2012
- Received 4 September 2010; revised 29 August 2011; accepted 9 September 2011.
- biological marker;
- clinical symptoms of schizophrenia;
- exploratory eye movement;
Aim: Many psychophysiological tests have been widely researched in the search for a biological marker of schizophrenia. The exploratory eye movement (EEM) test involves the monitoring of eye movements while subjects freely view geometric figures. Suzuki et al. (2009) performed discriminant analysis between schizophrenia and non-schizophrenia subjects using EEM test data; consequently, clinically diagnosed schizophrenia patients were identified as having schizophrenia with high probability (73.3%). The aim of the present study was to investigate the characteristics of schizophrenia patients who were identified as having schizophrenia on EEM discriminant analysis (SPDSE) or schizophrenia patients who were identified as not having schizophrenia on EEM discriminant analysis (SPDNSE).
Methods: The data for the 251 schizophrenia subjects used in the previous discriminant-analytic study were analyzed, and the demographic or symptomatic characteristics of SPDSE and SPDNSE were investigated. As for the symptomatic features, a factor analysis of the Brief Psychiatric Rating Scale (BPRS) rating from the schizophrenia subjects was carried out.
Results: Five factors were found for schizophrenia symptoms: excitement/hostility; negative symptoms; depression/anxiety; positive symptoms; and disorganization. SPDSE had significantly higher factor scores for excitement/hostility, negative symptoms and disorganization than SPDNSE. Furthermore, the BPRS total score for the SPDSE was significantly higher than that for the SPDNSE.
Conclusion: SPDSE may be a disease subtype of schizophrenia with severe symptoms related to excitement/hostility, negative symptoms and disorganization, and EEM parameters may detect this subtype. Therefore, the EEM test may be one of the contributors to the simplification of the heterogeneity of schizophrenia.