Platelet count alterations associated with escitalopram, venlafaxine and bupropion in depressive patients

Authors

  • Hoo Rim Song MD,

    1. Department of Psychiatry, Yeouido St Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul, Korea
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  • Young-Eun Jung MD,

    1. Department of Psychiatry, Yeouido St Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul, Korea
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  • Hee-Ryung Wang MD,

    1. Department of Psychiatry, Yeouido St Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul, Korea
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  • Young Sup Woo MD, PhD,

    1. Department of Psychiatry, Yeouido St Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul, Korea
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  • Tae-Youn Jun MD, PhD,

    1. Department of Psychiatry, Yeouido St Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul, Korea
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  • Won-Myong Bahk MD, PhD

    Corresponding author
    1. Department of Psychiatry, Yeouido St Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul, Korea
    • Won-Myong Bahk, MD, PhD, Department of Psychiatry, Yeouido St Mary's Hospital, College of Medicine, Catholic University of Korea, 62 Yeouidodong, Yeongdeungpogu, Seoul 150-713, Korea. Email: wmbahk@catholic.ac.kr

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Abstract

The objective of the present study was to evaluate changes in platelet counts on three different kinds of antidepressant. All subjects (n = 131) in their drug-naïve state had been diagnosed with depression. Escitalopram (n = 42), venlafaxine (n = 50) and bupropion (n = 39) were prescribed, and platelet count was measured before and after 1 month of treatment and compared. Decrease in platelet count on escitalopram was significant, while the others were not. These findings suggest that escitalopram may be associated with decreased platelet count, and bupropion is less likely to exert an influence on platelet count.

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