Discrimination of female schizophrenia patients from healthy women using multiple structural brain measures obtained with voxel-based morphometry
Article first published online: 17 DEC 2012
© 2012 The Authors. Psychiatry and Clinical Neurosciences © 2012 Japanese Society of Psychiatry and Neurology
Psychiatry and Clinical Neurosciences
Volume 66, Issue 7, pages 611–617, December 2012
How to Cite
Ota, M., Sato, N., Ishikawa, M., Hori, H., Sasayama, D., Hattori, K., Teraishi, T., Obu, S., Nakata, Y., Nemoto, K., Moriguchi, Y., Hashimoto, R. and Kunugi, H. (2012), Discrimination of female schizophrenia patients from healthy women using multiple structural brain measures obtained with voxel-based morphometry. Psychiatry and Clinical Neurosciences, 66: 611–617. doi: 10.1111/j.1440-1819.2012.02397.x
- Issue published online: 17 DEC 2012
- Article first published online: 17 DEC 2012
- Manuscript Accepted: 24 MAR 2012
- Manuscript Revised: 22 MAR 2012
- Manuscript Received: 18 NOV 2011
- Comprehensive Research on Disability, Health, and Welfare. Grant Numbers: H21-kokoro-001, H23-seisin-young scientist 013
- Neurological and Psychiatric Disorders of NCNP. Grant Numbers: 20-3, 21-9
- discriminant analysis;
- magnetic resonance imaging;
- structural deviation;
- voxel-based morphometry
Although schizophrenia and control subjects differ on a variety of neuroanatomical measures, the specificity and sensitivity of any one measure for differentiating between the two groups are low. To identify the correlative pattern of brain changes that best discriminate schizophrenia patients from healthy subjects, discriminant analysis techniques using voxel-based morphometry were applied.
The first analysis was conducted to obtain a statistical model that classified 105 female healthy subjects and 38 female schizophrenia patients. First, the differences in gray matter and cerebrospinal fluid volume between the patients and healthy subjects were evaluated using optimized voxel-based morphometry. Then, a discriminant analysis reflecting the results of this evaluation was adopted. The second analysis was performed to prospectively validate the statistical model by successfully classifying a new group that consisted of 23 female healthy subjects and 23 female schizophrenia patients.
The use of these variables resulted in correct classification rates of 0.72 in the control subjects and 0.76 in the schizophrenia patients. In the second validation analysis using these variables, correct classification rates of 0.70 in the control subjects and 0.74 in the schizophrenia patients were achieved.
Schizophrenia patients have structural deviations in multiple brain areas, and a combination of structural brain measures can distinguish between patients and controls.