Changes in heart rate variability during TOVA testing in patients with major depressive disorder
Article first published online: 21 JAN 2013
© 2013 The Authors. Psychiatry and Clinical Neurosciences © 2013 Japanese Society of Psychiatry and Neurology
Psychiatry and Clinical Neurosciences
Volume 67, Issue 1, pages 35–40, January 2013
How to Cite
Shen, T.-W., Liu, F.-C., Chen, S.-J. and Chen, S.-T. (2013), Changes in heart rate variability during TOVA testing in patients with major depressive disorder. Psychiatry and Clinical Neurosciences, 67: 35–40. doi: 10.1111/j.1440-1819.2012.02404.x
- Issue published online: 21 JAN 2013
- Article first published online: 21 JAN 2013
- Manuscript Accepted: 7 AUG 2012
- Manuscript Revised: 16 JUL 2012
- Manuscript Received: 6 MAR 2012
- Buddhist Tzu-Chi General Hospital, Hualien, Taiwan. Grant Number: TCRD98-42
- Tzu Chi University. Grant Number: CMRC-P-97006
- autonomic nervous system;
- heart rate variability;
- major depressive disorder;
- test of variables of attention
The aim of this study was to identify major depressive disorder (MDD) based on heart rate variability (HRV) during tests of variables of attention (TOVA).
Forty-five MDD patients without cardiovascular disease and 45 controls matched by age and gender participated in this study.
Compared to the controls, the MDD group had lower resting HRV parameters, more omissions and variability and longer response times on TOVA, and failure of attention employment to decrease HRV.
The resting HRV parameters may provide easily measured, clinically useful ways to identify patients with MDD and to monitor their progress in treatment.