Desmopressin accelerates the rate of urinary morphine excretion and attenuates withdrawal symptoms in rats
Version of Record online: 17 DEC 2012
© 2012 The Authors. Psychiatry and Clinical Neurosciences © 2012 Japanese Society of Psychiatry and Neurology
Psychiatry and Clinical Neurosciences
Volume 66, Issue 7, pages 594–601, December 2012
How to Cite
Saboory, E., Ghazizadeh, V., Heshmatian, B. and Khademansari, M. H. (2012), Desmopressin accelerates the rate of urinary morphine excretion and attenuates withdrawal symptoms in rats. Psychiatry and Clinical Neurosciences, 66: 594–601. doi: 10.1111/j.1440-1819.2012.02406.x
- Issue online: 17 DEC 2012
- Version of Record online: 17 DEC 2012
- Manuscript Accepted: 5 MAY 2012
- Manuscript Revised: 8 MAR 2012
- Manuscript Received: 5 OCT 2011
- Research Council of the Urmia University of Medical Sciences
- drug addiction;
- drug withdrawal;
The aim of this study was to examine the effects of desmopressin on morphine withdrawal symptoms and vasopressin level in morphine-dependent subjects.
Wistar male rats were injected s.c. with morphine once per day for 5 consecutive days to induce morphine dependence. After morphine use ceased on day 5, an equal number of rats were assigned to one of four groups for either saline or desmopressin by either intraperitoneal (i.p.) or intracerebroventricular (i.c.v.) injection. From days 5 to 10, urine was collected daily and tested for the presence of morphine, and withdrawal symptoms were monitored to assess the effects of desmopressin.
Significant weight loss occurred among all morphine-addicted rats during the withdrawal period. With both methods (i.p. and i.c.v.), the period of urinary morphine excretion was shorter for the two groups that were given desmopressin (experimental groups) than the two groups that were not given desmopressin (control groups), and no significant difference in urinary morphine excretion was found between the two experimental groups. During the early stage of withdrawal, the severity of the withdrawal symptoms in the experimental groups was significantly lower than that in the control groups.
Desmopressin decreases the extent of morphine withdrawal symptoms, indicating that this agent might be appropriate for treating morphine addiction. Desmopressin appears to reduce withdrawal symptoms not by exerting an anti-diuretic effect but rather by exerting an effect on the central nervous system.