Histological difference between complete responders and nonresponders to interferon therapy of the livers of patients with chronic hepatitis C
Article first published online: 11 DEC 2008
Volume 43, Issue 5, pages 230–236, May 1993
How to Cite
Uchida, T., Taira, M., Shikata, T., Moriyama, M., Tanaka, N., Okubo, H. and Arakawa, Y. (1993), Histological difference between complete responders and nonresponders to interferon therapy of the livers of patients with chronic hepatitis C. Pathology International, 43: 230–236. doi: 10.1111/j.1440-1827.1993.tb01137.x
- Issue published online: 11 DEC 2008
- Article first published online: 11 DEC 2008
- Received 11 November 1992. Accepted for publication 15 February 1993.
- chronic hepatitis;
- hepatitis C;
- liver histology;
- viral hepatitis
Liver histology was compared in patients with chronic hepatitis C to note the differences between responders and nonresponders to interferon treatment. Fifty-eight patients were administered interferon in varying doses and over various periods, and were then followed up for 1 year. According to the improvement status of serum alanine aminotransferase (ALT) levels during this period, the patients were classified into complete responders who showed complete normalization of ALT; partial responders who exhibited a significant decrease, but not complete normalization of ALT. Before application of the interferon treatment, liver biopsies were analyzed in four parameters and given scores from 0 to 5 for three groups in cord with no prior knowledge of the efficacy. The parameters included necroinflammation, fibrosis/lobular distortion, portal lymphocytic reaction and portal (or fibrous septal) outline destruction. Results indicated that there were no significant differences in the score of necroinflammation and portal lymphocytic reaction between the complete responder group and the nonresponder group. In contrast, the complete responder group exhibited weaker fibrosis/lobular distortion and less portal outline destruction than the non-responder group. The partial responder group was more akin to the former group in these parameters. Thus, it is safe to conclude that liver histology may predict the efficacy of interferon treatment.