Expression of matrix metalloproteinase (gelatinase) in T1 adenocarcinoma of the lung
Article first published online: 12 DEC 2008
© 1997 The Japanese Society of Pathology
Volume 47, Issue 7, pages 461–469, July 1997
How to Cite
Kodate, M., Kasai, T., Hashirnoto, H., Yasumoto, K., Iwata, Y. and Manabe, H. (1997), Expression of matrix metalloproteinase (gelatinase) in T1 adenocarcinoma of the lung. Pathology International, 47: 461–469. doi: 10.1111/j.1440-1827.1997.tb04525.x
- Issue published online: 12 DEC 2008
- Article first published online: 12 DEC 2008
- Received 29 August 1996. Accepted for publition 18 February 1997.
- matrix metalloproteinase;
- T1 adenocarcinoma of the lung
The expression of matrix mdalloproteinase-2 (MMP-2; 72 kDa type IV collagenase/gelatinase A) and MMP-9 (92 kDa type IV collagenase/gelatinase B) was Immunohisto chemically Investigated In 79 T1 adenocarcinomas of the lung using non-commerclal polydonal anti-MMP-2 and -9 antibodies. Thirty-two (41%) and 22 (28%) among the 79 cases were positive in the tumor cells for MMP-2 and -9, respectively. The incidences of MMP-2 and -9 Immunoreactivities were higher (64 and 45%, respectively) in poorly differentiated tumors than in well differentiated tumors (36 and 25%, respectively), and lower in bronchloloalveolar carcinoma (22 and 10%, respectively) compared with other subtypes of adenocarcinoma. The prognosis for patients with MMP-2 andor -9 positive Immunoreactivities was significantly poorer than for those with a MMP-negative tumor (P<0.05). The degree of collagenization was divided into four grades, and tumors with a small to abundant amount of collagen (grade 2 and grade 3 fibrosis) had a higher Incidence of Immunoreactivity to both types of MMP. It is estimated that these expressions might be responsible for tumor Invasion, metastasis, and for grade 2 and grade 3 fibrosis In T1 adenocarcinoma of the lung.