*Deparhnent of Pathology, Tohoku University School of Medicine, 2–1 Seiryo-machi, Aoba-ku, Sendai 980–8575. Email: firstname.lastname@example.org
Sarcomatous dermatofibrosarcoma protuberans metastasized to the lung: Preservation of CD34 expression in tumor cells
Article first published online: 12 DEC 2008
© 1998 Cambridge Philosophical Society
Volume 48, Issue 12, pages 989–993, December 1998
How to Cite
Ohtani, N., Fukusato, T. and Tezuka, F. (1998), Sarcomatous dermatofibrosarcoma protuberans metastasized to the lung: Preservation of CD34 expression in tumor cells. Pathology International, 48: 989–993. doi: 10.1111/j.1440-1827.1998.tb03872.x
- Issue published online: 12 DEC 2008
- Article first published online: 12 DEC 2008
- Received 11 May 1998. Accepted for publication 20 June 1998.
- dermatofibrosarcoma protuberans;
- fibrosarcomatous change;
- lung metastasis
A case of metastatic dermatofibrosarcoma protuberans (DFSP) In a 47-year-old woman is presented. Dermatofibrosarcoma protuberans occasionally recurs, but rarely metastasizes. The patient underwent local removal of the nuchal tumor by a general practitioner, followed by a rapid recurrence. She underwent total removal of the tumor and a diagnosis of spindle cell sarcoma was made after an Incisional biopsy was performed. This lesion had both a typical DFSP-like area and a flbrosarcoma (FS)-like area. After 7 years, an abnormal lung shadow was observed and a segmental lung redon was petformed. Histologically, the lung tumor was similar to the FS-like area in the nuchal tumor. Confirming CD34 expression in the tumor cells, this lung tumor was diagnosed as metastatic DFSP. Usually CD34 expression is unique to DFSP but almost negative in FS-like areas. In the present case, the FS-llke area in the nuchal tumor showed decreased CD34 reactivity, as previously reported, but the FS-like area In the metastatic tumor still widely preserved CD34 expression. The presented case suggests that the FS-like area in DFSP is histogenetically different from typical FS or malignant fibrous histiocytoma.