Gastric low-grade mucosa-associated lymphoid tissue lymphomas: Their histogenesis and high-grade transformation
Article first published online: 12 DEC 2008
© 1998 Cambridge Philosophical Society
Volume 48, Issue 5, pages 323–331, May 1998
How to Cite
Yoshino, T. and Akagi, T. (1998), Gastric low-grade mucosa-associated lymphoid tissue lymphomas: Their histogenesis and high-grade transformation. Pathology International, 48: 323–331. doi: 10.1111/j.1440-1827.1998.tb03914.x
- Issue published online: 12 DEC 2008
- Article first published online: 12 DEC 2008
- Received 6 November 1997. Accepted for publication 2 December 1997.
- Helicobacter pylori;
- mucosa-associated lymphoid tissue lymphoma;
Gastric low-grade mucosa-associated lymphoid tissue (MALT) lymphoma is a unique disease. A vast majority of lymphoma cells are centrocyte-like cells or resemble monocytold B cells, and occasionally show plasmacytic differentiation. Immunophenotypical and immunogeno-typical examinations have indicated that they are in the differentiation stage of memory B cells, whose normal counterparts are marginal zone lymphocytes or monocytoid B cells In the lymphoid tissues. It arises from chronic gastritis closely associated with Helicobacter pylori (H. pylori) infection. Mucosa-associated lymphoid tissue lymphomas of other organs are also based on acquired MALT associated with chronic inflammation or autoimmune diseases. Interestingly, the majority of gastric low-grade MALT lymphomas regress by the eradication of H. pylori. The lymphoma cells, however, are not derived from B cells reacting with H. pylori itself but from autoreactive B cells. Although the mechanism of their oncogenesis has not been clarified, previous data suggest that autoreactive B cells proliferate in response to H. pylori-specific T cells, presumably with some cytoklnes. The genetic Instability of such B cells then induces chromosomal abnormalities including trisomy 3 and/or other genetic changes. These B cells have the ability of autonomic proliferation and, even so, they might be sensitive to T cell stimuli. Low-grade gastric lymphomas occasionally progress to high-grade malignancy. The high-grade component of MALT lymphomas are composed of large-sized lymphoma cells that are morphologically indistinguishable from nodal large B cell lymphomas. This high-grade transformation is associated with p53 abnormalities or Bcl-6 overexpresslon. Gastric MALT lymphoma may provide a useful model in understanding multistep lymphomagenesls.