Low-grade fibromyxoid sarcoma arising in the big toe
Article first published online: 15 NOV 2005
Volume 55, Issue 12, pages 802–806, December 2005
How to Cite
Kusumi, T., Nishikawa, S., Tanaka, M., Ogawa, T., Jin, H., Sato, F., Toh, S., Hasegawa, T. and Kijima, H. (2005), Low-grade fibromyxoid sarcoma arising in the big toe. Pathology International, 55: 802–806. doi: 10.1111/j.1440-1827.2005.01910.x
- Issue published online: 15 NOV 2005
- Article first published online: 15 NOV 2005
- Received 27 June 2005. Accepted for publication 22 August 2005.
- hyalinized giant rosette;
- low-grade fibromyxoid sarcoma;
Low-grade fibromyxoid sarcoma (LGFMS) is a rare tumor. Reported herein is a case of LGFMS arising in the big toe. The patient was a 58-year-old man who underwent excision of the tumor. The tumor was well-demarcated. Histologically, there were proliferating spindle-shaped tumor cells arranged in a whorled growth pattern, and the stroma showed hyalinized collagen bundles and a myxoid matrix. Nuclear mitotic figures were conspicuous in part. A large rosette-like structure with hyalinized stroma was found, which is characteristic of LGFMS. The differential diagnosis included tumor occurrence in adults; tending to arise in distal extremities; and having bland fibromyxoid histological features, such as fibroma of tendon sheath, low-grade myxofibrosarcoma and acral myxoinflammatory fibroblastic sarcoma. It was not possible to detect the FUS/CREB3L2 and FUS/CREB3L1 fusion genes from the formalin-fixed and paraffin-embedded tissue, although the histological features of the present case were typical of LGFMS. LGFMS may become more common with time, and unique cases may accumulate.