Multiple IgG4-related sclerosing lesions in the maxillary sinus, parotid gland and nasal septum
Article first published online: 13 AUG 2009
© 2009 The Authors. Journal compilation © 2009 Japanese Society of Pathology
Volume 59, Issue 9, pages 670–675, September 2009
How to Cite
Ishida, M., Hotta, M., Kushima, R., Shibayama, M., Shimizu, T. and Okabe, H. (2009), Multiple IgG4-related sclerosing lesions in the maxillary sinus, parotid gland and nasal septum. Pathology International, 59: 670–675. doi: 10.1111/j.1440-1827.2009.02425.x
- Issue published online: 13 AUG 2009
- Article first published online: 13 AUG 2009
- Received 21 February 2009. Accepted for publication 27 April 2009.
- maxillary sinus;
- nasal septum;
- parotid gland;
- tumefactive fibroinflammatory lesion
IgG4-related sclerosing disease is recognized as a distinct clinicopathological entity. It is well known that this disease can occur in the salivary, lacrimal and pituitary glands, in the head and neck region. The nasal cavity is an extremely rare site of involvement of IgG4-related sclerosing disease. Herein is reported a case of multiple IgG4-related sclerosing lesions in the maxillary sinus, parotid gland and nasal septum. A 73-year-old Japanese man presented with nasal obstruction and tumors of the right maxillary sinus and parotid gland were detected, after which resections of these tumors were performed. One year after the last surgery, he noted swelling of the nasal septum, and the tumor was resected. These three tumors had similar histopathology, such as conspicuous fibrosclerotic changes with dense lymphoplasmacytic infiltration and occasional obliterative phlebitis. Immunohistochemistry indicated abundant IgG4-positive plasma cell infiltration and high ratios of IgG4-positive/IgG-positive plasma cells (>70%) in all three lesions. The diagnosis of multiple IgG4-related sclerosing lesions was made. The present case suggests that IgG4-related sclerosing lesion can occur in the maxillary sinus and nasal septum, and represents an extension of the spectrum of IgG4-related sclerosing disease.