Ratio of M2 macrophage expression is closely associated with poor prognosis for Angioimmunoblastic T-cell lymphoma (AITL)
Version of Record online: 22 FEB 2010
© 2010 The Authors. Journal compilation © 2010 Japanese Society of Pathology
Volume 60, Issue 4, pages 278–283, April 2010
How to Cite
Niino, D., Komohara, Y., Murayama, T., Aoki, R., Kimura, Y., Hashikawa, K., Kiyasu, J., Takeuchi, M., Suefuji, N., Sugita, Y., Takeya, M. and Ohshima, K. (2010), Ratio of M2 macrophage expression is closely associated with poor prognosis for Angioimmunoblastic T-cell lymphoma (AITL). Pathology International, 60: 278–283. doi: 10.1111/j.1440-1827.2010.02514.x
- Issue online: 17 MAR 2010
- Version of Record online: 22 FEB 2010
- Received 2 October 2009. Accepted for publication 20 November 2009.
- Angioimmunoblastic T-cell lymphoma;
- M2 macrophage
Angioimmunoblastic T-cell lymphoma (AITL) is a peripheral T-cell lymphoma characterized by systemic disease with polymorphous infiltrate including macrophages. Although many studies of tumor-associated macrophage (TAM) populations in various malignant tumors have been published, only a few have dealt with activation of macrophage phenotypes such as M1 and M2 in tumor tissue. Because M2 macrophages highly express CD163, we suspected that CD163 may be a useful marker for identification of activation of macrophage phenotypes in AITL. We performed a retrospective study of immunohistochemical expression using two markers for macrophages [CD68 (PG-M1), CD163] and of the correlation of these expressions with overall survival of 42 AITL patients. The number of CD68-positive cells in AITL tissues did not correlate with overall survival (P= 0.59), whereas the number of CD163-positive cells and overall survival correlated to some extent (P= 0.08). Meanwhile, a higher ratio of CD163-positive to CD68-positive cells in AITL significantly correlated with worse overall survival (P= 0.036). Considering that this ratio reflects the proportion of macrophages polarized to the M2 phenotype, our findings indicate that activation of macrophages towards the M2 phenotype correlates with worse prognosis. Our findings indicate that the ratio of M2 macrophages expressed may be a useful marker for prognosis of AITL.