Necrotizing sialometaplasia of the parotid gland associated with angiocentric T-cell lymphoma: A case report and review of the Literature
Article first published online: 8 FEB 2010
© 2010 The Authors. Journal compilation © 2010 Japanese Society of Pathology
Volume 60, Issue 4, pages 326–329, April 2010
How to Cite
Yoshioka, T., Harada, M., Umekita, Y., Taguchi, S., Higashi, M., Nakamura, D., Suzuki, S. and Tanimoto, A. (2010), Necrotizing sialometaplasia of the parotid gland associated with angiocentric T-cell lymphoma: A case report and review of the Literature. Pathology International, 60: 326–329. doi: 10.1111/j.1440-1827.2010.02518.x
- Issue published online: 17 MAR 2010
- Article first published online: 8 FEB 2010
- Received 20 August 2009. Accepted for publication 9 December 2009.
- necrotizing sialometaplasia;
- parotid gland;
- T-cell lymphoma
A very rare case of necrotizing sialometaplasia of the parotid gland associated with angiocentric T-cell lymphoma was described. A 66-year-old male had left neck and pharyngeal masses and biopsy specimen showed a monotonous proliferation of atypical lymphoid cells with massive necrosis in the parotid gland. Angiocentric pattern or vascular invasion by the lymphoid cells was observed and the involved parotid gland exhibited squamous metaplasia of the ducts and acini; necrotizing sialometaplasia. Immunohistochemical analysis revealed a cytotoxic T-cell phenotype of the lymphoid cells (CD3+, CD4-, CD5+, CD8+, CD56-, Granzyme B+, TIA-1+, Perforin-) but in situ hybridization showed no relation to Epstein-Barr virus. Although necrotizing sialometaplasia is relatively rare in the parotid gland, angiocentric T-cell lymphoma should be considered for a causative condition of necrotizing sialometaplasia.