Mixed adenoneuroendocrine carcinoma (MANEC) of the gallbladder: A possible stem cell tumor?

Authors

  • Alberto E. Paniz Mondolfi,

    Corresponding author
    1. Department of Pathology and Laboratory Medicine, St. Luke's-Roosevelt Hospital Center
    2. Department of Pathology and Laboratory Medicine, Beth Israel Medical Center
    3. Laboratorio de Bioquímica. Instituto de Biomedicina UCV, MSDS, IVSS, San Jose, Caracas, Venezuela.
    • Alberto E. Paniz Mondolfi, MD, Department of Pathology and Laboratory Medicine, St. Luke's-Roosevelt Hospital Center, St. Luke's Division, Clark 4, 1111 Tenth Avenue, New York, NY 10025, USA. Email: albertopaniz@yahoo.com

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  • Denisa Slova,

    1. Department of Pathology and Laboratory Medicine, St. Luke's-Roosevelt Hospital Center
    2. Department of Pathology and Laboratory Medicine, Beth Israel Medical Center
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  • Wen Fan,

    1. Department of Pathology and Laboratory Medicine, St. Luke's-Roosevelt Hospital Center
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  • Fadi F. Attiyeh,

    1. Department of Surgery, St. Luke's-Roosevelt Hospital Center
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  • John Afthinos,

    1. Department of Surgery, St. Luke's-Roosevelt Hospital Center
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  • Jason Reidy,

    1. Department of Pathology and Laboratory Medicine, Beth Israel Medical Center
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  • Yinghua Pang,

    1. Department of Pathology and Laboratory Medicine, St. Luke's-Roosevelt Hospital Center
    2. Department of Pathology and Laboratory Medicine, Beth Israel Medical Center
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  • Neil D. Theise

    1. Department of Pathology and Laboratory Medicine, Beth Israel Medical Center
    2. Department of Medicine, Division of Digestive Diseases, Beth Israel Medical Center, New York, New York, USA
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Abstract

A 48 year-old African American woman presented to her physician complaining of a rapidly evolving epigastric and right upper quadrant abdominal pain. A PET-CT of the abdomen and pelvis demonstrated hypermetabolic, polypoid masses within the gallbladder and several tumors in the left lobe of the liver for which she underwent diagnostic laparoscopy. The gallbladder revealed a 3.5 × 3.3 × 2.4 tan-brown exophytic mass located at the fundus and growing into the lumen with multiple contiguous papillary projections arising from the mucosal surface. A concurrent large cell neuroendocrine carcinoma and papillary adenocarcinoma of the gallbladder was revealed histologically. There was shared reactivity to antibodies directed against the distinct antigens for each morphological component with transitional tumor cells (of both histological components) located at the areas where the two tumor types merged, revealing common immunoreactivity for carcinoembryonic antigen, cancer antigen 19-9, keratin 19, c-kit (cluster of differentiation protein 117 (CD117)) and epithelial cell adhesion molecule. Ultrastructurally, individual cells were demonstrated to have overlapping features of neuroendocrine and glandular differentiation. The aforementioned histological, ultrastructural and immunohistochemical profile is strongly suggestive of a biphenotypic stem/progenitor cell tumor of the gallbladder.

Ancillary