Altered angiogenesis in the tumor microenvironment
Article first published online: 10 OCT 2011
© 2011 The Authors. Pathology International © 2011 Japanese Society of Pathology and Blackwell Publishing Asia Pty Ltd
Volume 61, Issue 11, pages 630–637, November 2011
How to Cite
Hida, K., Kawamoto, T., Ohga, N., Akiyama, K., Hida, Y. and Shindoh, M. (2011), Altered angiogenesis in the tumor microenvironment. Pathology International, 61: 630–637. doi: 10.1111/j.1440-1827.2011.02726.x
- Issue published online: 26 OCT 2011
- Article first published online: 10 OCT 2011
- Received 19 June 2011. Accepted for publication 20 July 2011.
- tumor endothelial cell;
- tumor microenvironment
Tumor blood vessels play an important role in tumor progression and metastasis. Thus, targeting the tumor blood vessels is an important strategy in cancer therapy. Tumor blood vessels generally arise from pre-existing vessels and have been thought to be genetically normal. However, they have been shown to differ from their normal counterparts, e.g. with regard to the morphological changes. We isolated tumor endothelial cells (TEC) from mouse tumor xenografts and showed that they were abnormal. TEC up-regulate many genes, proliferate more rapidly and migrate more than normal endothelial cells (NEC). Furthermore, the TEC in our study were cytogenetically abnormal. We concluded that TEC can acquire cytogenetic abnormalities while in the tumor microenvironment. In order to develop ideal antiangiogenic therapies, understanding the crosstalk between blood vessels and the tumor microenvironment is important. This review considers the current studies on TEC abnormalities and discusses the possible mechanism by which the tumor microenvironment produces abnormal TEC.