A clinicopathological and immunohistological re-evaluation of adenosquamous carcinoma of the lung
Article first published online: 14 OCT 2011
© 2011 The Authors. Pathology International © 2011 Japanese Society of Pathology and Blackwell Publishing Asia Pty Ltd
Volume 61, Issue 12, pages 717–722, December 2011
How to Cite
Shimoji, M., Nakajima, T., Yamatani, C., Yamamoto, M., Saishou, S., Isaka, M., Maniwa, T., Ode, Y., Nakagawa, K., Okumura, T., Watanabe, R., Ito, I., Kameya, T., Endo, M. and Kondo, H. (2011), A clinicopathological and immunohistological re-evaluation of adenosquamous carcinoma of the lung. Pathology International, 61: 717–722. doi: 10.1111/j.1440-1827.2011.02730.x
- Issue published online: 29 NOV 2011
- Article first published online: 14 OCT 2011
- Received 25 March 2011. Accepted for publication 22 July 2011.
- adenosquamous carcinoma;
- fluorodeoxyglucose positron emission tomography;
Since the World Health Organization histological criteria were published in 1999, several studies have focused on adenosquamous carcinoma of the lung. Therefore, we aimed to clinicopathologically re-evaluate this tumor using immunohistochemical methods. In our hospital, there have been 21 surgically resected adenosquamous carcinomas. The frequency of adenosquamous carcinoma was 1.9% and the clinical data including the patient prognosis data obtained in this study were similar to those reported previously. A fluorodeoxyglucose positron emission tomography study first revealed that the median maximum standardized uptake value of adenosquamous carcinoma was 9.3 and ranged from 2.0 to 24.5. According to the results of immunohistochemical staining for thyroid transcription factor-1 (TTF-1) and p63, adenosquamous carcinomas were divided into four subgroups: group 1, TTF-1+ and p63+ (10 cases); group 2, TTF-1- and p63+ (six cases); group 3, TTF-1+ and p63- (three cases); and group 4, TTF-1- and p63- (two cases). Of the six group 2 tumors, three were composed of unique solid nests with mucin-filled cysts and showed characteristic p63 expression, which might suggest a special type of adenosquamous carcinoma. Immunohistochemical analysis of TTF-1 and p63 expression shows that adenosquamous carcinoma is composed of diverse tumor groups, for which the biological and histogenetic nature further needs to be clarified.