Intraductal papillary neoplasm arising from peribiliary glands connecting with the inferior branch of the bile duct of the anterior segment of the liver
Article first published online: 29 NOV 2011
© 2011 The Authors. Pathology International © 2011 Japanese Society of Pathology and Blackwell Publishing Asia Pty Ltd
Volume 61, Issue 12, pages 773–777, December 2011
How to Cite
Nakanishi, Y., Nakanuma, Y., Ohara, M., Iwao, T., Kimura, N., Ishidate, T. and Kijima, H. (2011), Intraductal papillary neoplasm arising from peribiliary glands connecting with the inferior branch of the bile duct of the anterior segment of the liver. Pathology International, 61: 773–777. doi: 10.1111/j.1440-1827.2011.02738.x
- Issue published online: 29 NOV 2011
- Article first published online: 29 NOV 2011
- Received 10 June 2011. Accepted for publication 15 August 2011.
- biliary cystic tumor;
- gastric type;
- intraductal papillary neoplasm of the bile duct;
- peribiliary gland
Intraductal papillary neoplasms of the bile duct are generally thought to arise from neoplastic papillary proliferation of epithelial cells lining the bile duct. We herein report a case with findings that strongly suggested that the biliary cystic tumor might have derived from a peribiliary gland. A 69-year-old female was found to have a cystic lesion with intracystic protrusions at the anterior segment of the right hepatic lobe and underwent hepatic anterior segment resection. Fluoroscopy of the resected specimen injected with contrast medium into the cyst revealed a connection between the cystic lesion and the bile ducts. The cyst was multilocular in appearance. On microscopic examination, the cyst was located within the portal tract of the inferior branch of the anterior segment and connected with the inferior branch of the bile duct. The wall of the hepatic cyst lacked an ovarian-like stroma. The tumor was composed of papillary and glandular components, and the tumor cells were similar to gastric foveolar and pyloric gland epithelia and regarded as adenoma. These tumor cells were positive for MUC 5AC, MUC6, and HIK1083. The tumor was finally diagnosed as an intraductal papillary neoplasm of the bile duct (adenoma, gastric type) arising from a peribiliary gland.